As of the census of 2000, there were 42,249 people, 16,793 households, and 10,243 families residing in the city. The population density was 3,216.9 inhabitants per square mile (1,242.4/km2). There were 17,849 housing units at an average density of 1,359.1 per square mile (524.9/km2). The ethnic makeup of the city was 47.7% White (Non Hispanic), 46.64% Hispanic or Latino of any race, 3.30% Black or African American, 0.13% Native American, 1.68% Asian, 0.04% Pacific Islander, 1.49% from other races, and 1.54% from two or more races.
There were 16,793 households out of which 24.2% had children under the age of 18 living with them, 49.2% were married couples living together, 9.1% had a female householder with no husband present, and 39.0% were non-families. 31.5% of all households were made up of individuals and 9.8% had someone living alone who was 65 years of age or older. The average household size was 2.31 and the average family size was 2.92.
In the city the population was spread out with 17.4% under the age of 18, 13.9% from 18 to 24, 29.0% from 25 to 44, 23.9% from 45 to 64, and 15.8% who were 65 years of age or older. The median age was 38 years. For every 100 females there were 87.6 males. For every 100 females age 18 and over, there were 85.6 males.
According to a 2007 estimate, the median income for a household in the city was $78,157, and the median income for a family was $121,651. Males had a median income of $66,178 versus $39,444 for females. The per capita income for the city was $46,163. About 4.3% of families and 6.9% of the population were below the poverty line, including 5.6% of those under age 18 and 6.0% of those age 65 or over.
In 2000, Spanish was spoken as a first language by 51.05% of residents, while English was the first language of 43.82%, French 1.08%, Portuguese 0.79%, and Italian 0.72% of the population.
As of 2000, Coral Gables had the eighteenth highest percentage of Cuban residents in the US, with 28.72% of the populace. It also had the sixty-fourth highest percentage of Colombian residents in the US, at 2.27% of the city's population, and the sixteenth highest percentage of Venezuelan residents in the US, at 1.17% of its population.