• The University of Miami has been the largest employer in Coral Gables since the city's beginning.
  • Bacardi has its headquarters with 300 employees at 2701 Le Jeune Road.
  • Intelsat has its Latin American headquarters in Suite 1100 at One Alhambra Plaza.
  • Fresh Del Monte Produce has its headquarters in Coral Gables.
  • ExxonMobil has marine fuels operations in Suite 900 at One Alhambra Plaza in Coral Gables.
  • Aeroméxico operates a ticket office in Suite 102 at Two Alhambra Plaza.
  • American Airlines maintains the Ponce de Leon Travel Center at 901 Ponce De Leon Boulevard.
  • MoneyGram has its Miami Office in Coral Gables.
  • Dolphin Entertainment is an independent film studio that is located in Coral Gables
  • By 2006 Burger King had announced that it planned to move its headquarters to a proposed office building in Coral Gables. By 2007 Burger King instead renewed the lease in its existing headquarters for 15 years. Burger King planned to consolidate employees working at an area near Miami International Airport and at a Dadeland Mall-area facility into the current headquarters by June of that year. Instead Bacardi USA leased the headquarters complex, a 15-story building. Bacardi consolidated employees from seven separate buildings in South Florida.